Effect of a Chitosan-Based Biodegradable Middle Meatal Dressing after Endoscopic Sinus Surgery: A Prospective Randomized Comparative Study
نویسندگان
چکیده
Introduction: The use of biomaterials to improve wound healing after endoscopic sinus surgery (ESS) is not new. Many types of resorbable and non-resorbable materials have been tried as a middle meatal (MM) dressing, spacer, or stent to prevent lateralization of the middle turbinate, formation of synechia, granulation tissue, adhesions and scarring. The FDA has recently approved Chitosan-based nasal dressing/spacers which have optimal wound healing characteristics, including hemostatic and bacteriostatic properties. Herein, we compare a new chitosan-based biomaterial to a popular fully synthetic resorbable dressing in patients undergoing ESS. Materials and Methods: A prospective randomized controlled study was performed comparing a new Chitosan-based bioresorbable nasal dressing (Posi-Sep X) against a previously studied and well known fully synthetic polyurethane-based control (Nasopore). Post-operative outcome metrics included the degree of crusting, amount of retained implant, patient comfort, wound healing, epistaxis, and post-operative infection at two weeks. Results: Thirty-five patients were enrolled and a total seventy implants were placed (n = 70) at the completion of ESS. The results show a statistically significant difference between the Chitosan-based product and the control with respect to wound healing, degree of crusting, and resorption profile. In addition, the Chitosan-based dressing had a markedly lower requirement for post-operative debridement, and a lower incidence of OPEN ACCESS
منابع مشابه
Efficacy and Safety of Guardcel Nasal Packing After Endoscopic Sinus Surgery: A Prospective, Single-Blind, Randomized Controlled Study
OBJECTIVES Nasal packing after endoscopic sinus surgery is frequently used to control postoperative bleeding, enhance the wound healing process, and prevent lateralization of the middle turbinate, which causes insufficient ventilation. Many biodegradable materials have been developed to reduce pain and mucosal damage during packing removal. The purpose of this study was to compare the efficacy ...
متن کاملA double-blind randomised controlled trial of gloved versus ungloved merocel middle meatal spacers for endoscopic sinus surgery.
BACKGROUND Middle meatal spacers are commonly used following endoscopic sinus surgery to prevent post-operative bleeding and lateralization of the middle turbinates. The effects of nasal packing on post-operative sinonasal mucosal healing remain unknown in humans. OBJECTIVE This study aims to compare the histopathalogical effects of Merocel and Merocel covered with a finger glove on mucosal h...
متن کاملClinical evaluation of a fully synthetic middle meatal stent for safety and tolerability.
OBJECTIVE To evaluate the safety and tolerability of a novel, fully synthetic, poly-urethane middle meatal dressing after endoscopic sinus surgery (ESS). STUDY DESIGN Case series with planned data collection. SETTING Tertiary care medical facility. SUBJECTS AND METHODS In total, 104 patients with medically refractory chronic rhinosinusitis were treated with patient-appropriate ESS and a p...
متن کاملSmell Decline as a good Predictor of Sinonasal Polyposis Recurrence after Endoscopic Surgery
Introduction: To evaluate the most sensitive symptom to predict early recurrence of nasal polyposis. Prospective longitudinal cohort study. Tertiary university referral center with accredited otorhinolaryngology residency programs. Materials and Methods: In this prospective study, we evaluated 62 patients with diffuse nasal polyposis. All patients underwent functional endoscopic sinus surgery...
متن کاملEvaluation of Silastic Splints following Endoscopic Sinus Surgery
Middle meatal adhesions are considered the most common complication of Functional Endoscopic Sinus Surgery (FESS), ranging in incidence from 1 to 36%. Consequently the recurrence and persistence of symptoms increase, resulting in revision surgery in up to 25% of the cases. Although different methods have been attempted to prevent adhesions, each procedure involves some disadvantages and no stan...
متن کامل